Year: 2015
Type: article
Abstract: Forkhead box O (Foxo) transcription factors may be involved in the salutary effect of dietary restriction (DR). This study examined the role of Foxo3 in lifespan extension and cancer suppression in DR mice. Wild-type (WT) and Foxo3-knockout heterozygous ((+/-) ) and homozygous ((-/-) ) mice were subjected to a 30% DR regimen initiated at 12 weeks of age. Control mice were fed ad libitum (AL) throughout the study. In contrast to WT mice, DR did not significantly extend the lifespan of Foxo3(+/-) or Foxo3(-/-) mice. However, DR reduced the prevalence of tumors at death in WT, Foxo3(+/-) , and Foxo3(-/-) mice. These results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR. The findings in Foxo3(+/-) mice contrast with those in Foxo1(+/-) mice reported previously by our laboratory suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo3.
Source: Aging Cell
DOI: 10.1111/acel.12340
Authors: Isao Shimokawa, Toshimitsu Komatsu, Nobutaka Hayashi, Sang‐Eun Kim, Takuya Kawata, Seongjoon Park, Hiroko Hayashi, Haruyoshi Yamaza, Takuya Chiba, Ryoichi Mori
Institution: Nagasaki University
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,790
Awards: Circulating-miRNA in peripheral blood in metabolic state of between distant organs, Study of the anti-aging effects of stem cells from human exfoliated deciduous teeth using progeria mice, Regulation of aging in mammals : Difference between the effects of calorie restriction and suppression of the GH-IGF-1 axis, Regulation of cancer and aging by FoxO and investigation of compounds for regulation of FoxO, Establishment of Anti-aging mechanism by NPY in the fat metabolism, Molecular mechanism of inflammation-related miRNA in tissue repair and antisense oligodeoxynucleotide development, Functional analysis for lifestyle diseases-related molecules based on molecular epidemiologic study
OpenAlex ID: W2045418941