Year: 2008
Type: article
Abstract: In this study, we investigated the role of serum amyloid A protein (SAA) in the production of interleukin-6 (IL-6) using rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Recombinant SAA stimulation induced the production of pro-inflammatory cytokine, IL-6, from RA-FLS. The signaling events induced by SAA included the activation of the mitogen-activated protein kineases, p38 and JNK1/2 and the activation of nuclear factor-kappa B (NF-kappaB). Inhibitor studies have shown SAA-induced IL-6 production to be down-regulated by NF-kappaB inhibition and partially inhibited by p38 or JNK inhibitors. Our findings demonstrate that SAA is a significant inducer of IL-6, which is critically involved in RA pathogenesis.
Source: FEBS Letters
Authors: Tomohiro Koga, Takafumi Torigoshi, Satoru Motokawa, Taichiro Miyashita, Yumi Maeda, Minoru Nakamura, Atsumasa Komori, Yoshihiro Aiba, Takashi Uemura, Hiroshi Yatsuhashi, Hiromi Ishibashi, Katsumi Eguchi, Kiyoshi Migita
Institutions: Nagasaki Medical Center, Nagasaki University
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2045599643