Work

A search for human T‐cell leukemia virus type I in the lesions of patients with tropical spastic paraparesis and polymyositis

Year: 1995

Type: article

Abstract: We searched for the presence of human T-cell leukemia virus type I (HTLV-I) sequences in central nervous system and muscle lesions of 3 patients with tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) and 3 patients with HTLV-I-associated polymyositis. Proviral DNA coding for the Tax protein was found by polymerase chain reaction amplification in DNA extracted from lesions of every patient with TSP/HAM or HTLV-I-associated polymyositis. In contrast, viral RNA was found occasionally by in situ hybridization in muscle lesions of some patients with polymyositis, but was never found in central nervous system lesions of TSP/HAM patients.

Source: Annals of Neurology

DOI: 10.1002/ana.410380317

Authors: Frédéric Tangy, Jean‐Claude Vernant, Laurent Coscoy, Marlène Ossondo, RéMi Bellance, Vladimir Zaninovic, Luis Cartier, Michel Brahic, Simona Ozden

Institutions: Institut Pasteur, Hospital Universitario del Valle ESE, University of Chile

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2045839196

FWCI: 0.692

Cites: 22

Cited by: 19

Related to: 10