Familial microcephaly with normal intelligence in a patient with acute lymphoblastic leukemia
Year: 1992
Type: article
Study design: Case Report
Abstract: The authors describe a family with two children with microcephaly and normal intelligence, in which acute lymphoblastic leukemia developed in one of the siblings. An autosomal recessive pattern of inheritance is suggested by the pedigree. This is consistent with the literature, which the authors reviewed. All of the patients have similar phenotypic features, with some demonstrating chromosomal instability. It is important to recognize this syndrome because of the increased risk of lymphoreticular malignancy.
Source: Cancer
Institutions: St James's University Hospital, Leeds General Infirmary
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2045878298