Work

Differential Adaptive Responses of Staphylococcus aureus to In Vitro Selection with Different Antimicrobial Peptides

Year: 2013

Type: article

Abstract: We subjected Staphylococcus aureus ATCC 29213 to serial passage in the presence of subinhibitory concentrations of magainin 2 and gramicidin D for several hundred generations. We obtained S. aureus strains with induced resistance to magainin 2 (strain 55MG) and gramicidin D (strain 55GR) that showed different phenotypic changes in membrane properties. Both exhibited a change in membrane phospholipid content and an increase in membrane rigidity, while an alteration in net charge compared to that of the control occurred only in the case of 55MG.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00780-13

Authors: Tahsina Shireen, Madhuri Singh, Tiyasa Das, Kasturi Mukhopadhyay

Institution: Jawaharlal Nehru University

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Indian Council of Medical Research, University Grants Commission