Work

Enzyme-Based Logic: OR Gate with Double-Sigmoid Filter Response

Year: 2012

Type: article

Abstract: The first realization of a biomolecular OR gate function with double-sigmoid response (sigmoid in both inputs) is reported. Two chemical inputs activate the enzymatic gate processes, resulting in the output signal: chromogen oxidation, which occurs when either one of the inputs or both are present (corresponding to the OR binary function), and can be optically detected. High-quality gate functioning in handling of sources of noise is enabled by "filtering" involving pH control with an added buffer. The resulting gate response is sigmoid in both inputs when proper system parameters are chosen, and the gate properties are theoretically analyzed within a model devised to evaluate its noise-handling properties.

Source: The Journal of Physical Chemistry B

DOI: 10.1021/jp305183d

Authors: Oleksandr Zavalov, Vera Bocharova, Vladimir Privman, Evgeny Katz

Institutions: Clarkson University, Oak Ridge National Laboratory

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, Division of Chemical, Bioengineering, Environmental, and Transport Systems

Awards: G2414303008, Collaborative Research: Multi-Input Biosensors with Built-In Logic, SHF: Small: Experimental and Theoretical Development of Error Correction and Digitalization Concepts for Multi-Enzyme Biomolecular Computing Networks