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Cytotoxic Benzophenone Derivatives from Garcinia Species Display a Strong Apoptosis-Inducing Effect against Human Leukemia Cell Lines.

Year: 2003

Type: article

Abstract: We examined the in vitro effects of the benzophenone derivatives garcinol, isogarcinol, and xanthochymol on cell growth in four human leukemia cell lines. All of the compounds exhibited significant growth suppression due to apoptosis mediated by the activation of caspase-3. A loss of mitochondrial membrane potential was found in garcinol- and isogarcinol-induced apoptosis, but not in xanthochymol-induced apoptosis. The growth inhibitory effects of isogarcinol and xanthochymol were more potent than that of garcinol, which is a well- known cytotoxic benzophenone derivative.

Source: Biological and Pharmaceutical Bulletin

DOI: 10.1248/bpb.26.569

Authors: Kenji Matsumoto, Yukihiro Akao, Emi Kobayashi, Tetsuro Ito, Kenji Ohguchi, Toshiyuki Tanaka, Munekazu Iinuma, Yoshinori Nozawa

Institutions: Gifu Pharmaceutical University, Gifu Prefectural Research Institute for Health and Environmental Sciences

Language: English

Topic: Natural Compound Pharmacology Studies

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2050196587

FWCI: 3.664

Cites: 7

Cited by: 112

Related to: 10