Year: 2013
Type: article
Study design: Case Report
Abstract: Genetic MedicineInversions are balanced rearrangements of chromosomes, and the vast majority of paracentric inversions seem to be harmless.5) The risk of having a phenotypically abnormal child for carriers of paracentric inversions due to the production of unbalanced gametes resulting from recombination during meiotic crossover has been thought to be low.6) However, a few cases of abnormal offspring due to classic recombination of inversion have been described.Spontaneous abortion, infertility, and mental retardation and/or congenital malformation of offspring have also been reported among paracentric inversion carriers.2) In this study, we characterized paracentric inversions identified in 10 cases observed in prenatal diagnosis at our center during a five-year period.
Source: Journal of genetic medicine
Authors: Shin Yeong Lee, Bom Yi Lee, Ju Yeon Park, Eun Young Choi, Yeon Woo Lee, Ah Rum Oh, Hyun Mee Ryu, So Yeon Park
Institution: Cheil General Hospital and Women's Healthcare Center
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2050991997