Work

MicroRNAs as potential clinical biomarkers: emerging approaches for their detection

Year: 2013

Type: article

Abstract: MicroRNAs (miRNAs) have emerged as novel post-transcriptional regulators of gene expression. These short non-coding RNAs are involved in diverse biological processes and their dysregulation is often observed under diseased conditions. Therefore, miRNAs hold great potential as clinical biomarkers of physiological and pathological states and extensive efforts are underway to develop efficient approaches for their detection. We review recent advances and discuss the promises and pitfalls of emerging methods of miRNA profiling and detection.

Source: Biotechnic & Histochemistry

DOI: 10.3109/10520295.2012.730153

Authors: SK Srivastava, A Bhardwaj, SJ Leavesley, WE Grizzle, S Singh, AP Singh

Institutions: University of South Alabama, University of Alabama at Birmingham, USA Mitchell Cancer Institute

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute