Work

Why Don't CD8+ T Cells Reduce the Lifespan of SIV-Infected Cells In Vivo?

Year: 2011

Type: article

Abstract: In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.

Source: PLoS Computational Biology

DOI: 10.1371/journal.pcbi.1002200

Authors: Marjet Elemans, Nafisa-Katrin Seich al Basatena, Nichole R. Klatt, Christos Gkekas, Guido Silvestri, Becca Asquith

Institutions: Imperial College London, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Emory University

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,043