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Reactions of Quinoline and 4-Chloroquinoline 1-Oxides with Phenoxyacetonitrile, Chloromethylphenylsulfone, and Methylthiomethyl-p-tolylsulfone

Year: 1987

Type: article

Abstract: Quinoline and 4-chloraquinoline 1-oxides react with phenoxyacetonitrile (1) and chloromethylphenylsulfone (3) in KOH-DMSO and in t-BuOK-THF to give the respective vicarious nucleophilic substitution products, 2-cyanomethyl-(La and 2J) and 2phenylsulfonylmethylquinoline 1-oxides ( 4 3 and 49).The reactions with methylthiomethyl-p-tolylsulfone (2) afford not only

Source: Heterocycles

DOI: 10.3987/s-1987-01-0229

Authors: Masatomo Hamana, Yasuo Fujimura, Terushi Haradahira

Institutions: Kyushu University, Chugai Pharmaceutical Co., Ltd. (Japan)

Language: English

Topic: Synthesis and Reactivity of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W2051829751

FWCI: 2.695

Cites:

Cited by: 15

Related to: 10