Machine Learning Methods Enable Predictive Modeling of Antibody Feature:Function Relationships in RV144 Vaccinees
Year: 2015
Type: article
Abstract: The adaptive immune response to vaccination or infection can lead to the production of specific antibodies to neutralize the pathogen or recruit innate immune effector cells for help. The non-neutralizing role of antibodies in stimulating effector cell responses may have been a key mechanism of the protection observed in the RV144 HIV vaccine trial. In an extensive investigation of a rich set of data collected from RV144 vaccine recipients, we here employ machine learning methods to identify and model associations between antibody features (IgG subclass and antigen specificity) and effector function activities (antibody dependent cellular phagocytosis, cellular cytotoxicity, and cytokine release). We demonstrate via cross-validation that classification and regression approaches can effectively use the antibody features to robustly predict qualitative and quantitative functional outcomes. This integration of antibody feature and function data within a machine learning framework provides a new, objective approach to discovering and assessing multivariate immune correlates.
Source: PLoS Computational Biology
Institutions: Dartmouth College, Harvard University, Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Massachusetts Institute of Technology, Ministry of Public Health, Department of Disease Control, Mahidol University, Armed Forces Research Institute of Medical Science, Global Solutions for Infectious Diseases, Henry M. Jackson Foundation, Walter Reed Army Institute of Research
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,043
Funders: National Science Foundation, U.S. Department of Defense, Amgen, Henry M. Jackson Foundation, American Australian Association, National Institutes of Health, U.S. Public Health Service, National Health and Medical Research Council, U.S. Military HIV Research Program, Medical Research and Materiel Command
Awards: G1103249167, G1546679804, G1589278233, G2394943125, G4119534169, III: Medium: Collaborative Research: Integration, Prediction, and Generation of Mixed Mode Information using Graphical Models, with Applications to Protein-Protein Interactions, G5637606854, G5850682332, G7271599376, G8105216508, G8287382998, US MILITARY HUMAN IMMONODEFIECIENCY VIRUS (HIV) RESEARCH PROGRAM, Comparison of Antibodies from HIV-1 Human Vaccine Trials
OpenAlex ID: W2052200679