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Histone deacetylase 3 is selectively involved in L3MBTL2‐mediated transcriptional repression

Year: 2010
Type: article
Abstract: This is the first report that L(3)mbt-like 2 (L3MBTL2) specifically interacts with the histone deacetylase domain of histone deacetylase 3 (HDAC3) via its MBT domain. Here, we show that L3MBTL2 selectively interacts with HDAC3, but not other class I HDACs. An in vitro peptide-binding assay demonstrated the specific association of HDAC3 with methylated histone-K20 tail and L3MBTL2. Furthermore, depletion of HDAC3 resulted in a decrease of methylated K20-H4, as well as an increase in acetylated histone H3. Consequently, HDAC3 knock-down selectively suppressed L3MBTL2-mediated transcriptional repression. Taken together, our results reveal the concerted action of both HDAC3 and L3MBTL2 in histone deacetylation and methylation-dependent transcriptional repression.
Source: FEBS Letters
DOI: 10.1016/j.febslet.2010.03.048
Authors: Jung-Yoon Yoo, Kyung-Chul Choi, HeeBum Kang, Young Jun Kim, Jeongmin Lee, Woo Jin Jun, Mi-Jeong Kim, Yoo-Hyun Lee, Ok-Hee Lee, Ho-Geun Yoon
Institutions: Yonsei University, Korea University, Kyung Hee University, Chonnam National University, University of Suwon, Severance Hospital, Yonsei University Health System
Language: English
Open Access status: green
OpenAlex ID: W2052353620
FWCI: 0.425
Cites: 12
Cited by: 14
Related to: 10