HLA-partially matched cellular therapy (stem-cell microtransplantation) for acute myeloid leukaemia: description of four cases
Year: 2014
Type: article
Study design: Case Report
Abstract: HLA-partially matched cellular therapy (stem-cell microtransplantation) for acute myeloid leukaemia: description of four cases Donor leucocyte infusions (DLI) after conventional chemotherapy have been proposed as a treatment for acute myeloid leukaemia (AML).This procedure has been successfully employed in AML elderly patients (Guo et al, 2011;Cignetti et al, 2013), low and intermediate-risk AML as post-remission therapy (Guo et al, 2012) and myelodysplastic syndromes (MDS) (Ai et al, 2012).In our centre, using a similar approach, we have performed nine human leucocyte antigen (HLA)-partially matched donor leucocyte infusions (PM-DLI) in four elderly patients, three of which were HLA-haploidentical (Table I).After obtaining institutional ethics approval, one or two apheresis of related donor peripheral mononuclear cells were collected after granulocyte colony-stimulating factor (filgrastim) mobilization.The procedure was employed as post-remission therapy in three cases (2 de novo intermediate-risk AML and 1
Source: British Journal of Haematology
DOI: 10.1111/bjh.12771
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2053374870