Year: 2009
Type: article
Abstract: The quartz crystal microbalance sensor has a resonant frequency f and a quality factor Q which can be used to probe the properties of nanometer thick film loads. A recent review by Arnau (2008) has discussed many of the considerations necessary to accurately probe for these properties. To avoid needless duplication but to still provide an adequate background for the new user, we briefly outline the basic measurement methodologies and analytical techniques that were covered in the review. Details will be provided on some specific perspectives of the authors. For example, the special precautions necessary when dealing with soft films (polymeric and biological) under liquid are overviewed. To illustrate applications of the QCM technique, simple bilayer and vesicle behaviors are discussed, along with the structural transformation resulting from protein adsorption onto an intact vesicle adlayer. The amphipathic α‐helical (AH) peptide interaction is given as a particular example. Lastly, we summarize a top‐down approach to functionalize a surface with a cell membrane and to study its interaction with proteins.
Source: Journal of Sensors
DOI: 10.1155/2009/824947
Authors: K. Kanazawa, Nam-Joon Cho
Institutions: Stanford University, Stanford Medicine
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,830
OpenAlex ID: W2054863253