Structural Characteristics and Anticancer Activity of Fucoidan from the Brown Alga Sargassum mcclurei
Year: 2013
Type: article
Abstract: Three different fucoidan fractions were isolated and purified from the brown alga, Sargassum mcclurei. The SmF1 and SmF2 fucoidans are sulfated heteropolysaccharides that contain fucose, galactose, mannose, xylose and glucose. The SmF3 fucoidan is highly sulfated (35%) galactofucan, and the main chain of the polysaccharide contains a →3)-α-L-Fucp(2,4SO₃⁻)-(1→3)-α-L-Fucp(2,4SO₃⁻)-(1→ motif with 1,4-linked 3-sulfated α-L-Fucp inserts and 6-linked galactose on reducing end. Possible branching points include the 1,2,6- or 1,3,6-linked galactose and/or 1,3,4-linked fucose residues that could be glycosylated with terminal β-D-Galp residues or chains of alternating sulfated 1,3-linked α-L-Fucp and 1,4-linked β-D-Galp residues, which have been identified in galactofucans for the first time. Both α-L-Fucp and β-D-Galp residues are sulfated at C-2 and/or C-4 (and some C-6 of β-D-Galp) and potentially the C-3 of terminal β-D-Galp, 1,4-linked β-D-Galp and 1,4-linked α-L-Fucp residues. All fucoidans fractions were less cytotoxic and displayed colony formation inhibition in colon cancer DLD-1 cells. Therefore, these fucoidan fractions are potential antitumor agents.
Source: Marine Drugs
DOI: 10.3390/md11051456
Authors: Pham Thinh, Roza Menshova, Svetlana Ermakova, Stanislav Anastyuk, Bui Ly, Tatiana Zvyagintseva
Language: English
Subfield: Aquatic Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,499
OpenAlex ID: W2056734355