Work

Enzymatic AND Logic Gate with Sigmoid Response Induced by Photochemically Controlled Oxidation of the Output

Year: 2013

Type: article

Abstract: We report a study of a system which involves an enzymatic cascade realizing an AND logic gate, with an added photochemical processing of the output, allowing the gate's response to be made sigmoid in both inputs. New functional forms are developed for quantifying the kinetics of such systems, specifically designed to model their response in terms of signal and information processing. These theoretical expressions are tested for the studied system, which also allows us to consider aspects of biochemical information processing such as noise transmission properties and control of timing of the chemical and physical steps.

Source: The Journal of Physical Chemistry B

DOI: 10.1021/jp404054f

Authors: Vladimir Privman, Brian E. Fratto, Oleksandr Zavalov, Jan Halámek, Evgeny Katz

Institution: Clarkson University

Language: English

Topic: Gene Regulatory Network Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, Division of Chemical, Bioengineering, Environmental, and Transport Systems

Awards: G2414303008, Collaborative Research: Multi-Input Biosensors with Built-In Logic, SHF: Small: Experimental and Theoretical Development of Error Correction and Digitalization Concepts for Multi-Enzyme Biomolecular Computing Networks