Work

Evaluation of Strategies for the Synthesis of the Guanidine Hemiaminal Portion of Palau’amine

Year: 2006

Type: article

Abstract: Potential methods for the generation of the guanidine hemiaminal functionality of palau'amine (1) from a spirocyclic thiohydantoin precursor are examined using a spirobicyclic model system, culminating in the identification of an efficient means of effecting this transformation.† In recognition of his many contributions to organic synthesis and heterocyclic chemistry, this contribution is dedicated to a close friend, Steven Weinreb, on the occasion of his 65th birthday.

Source: Heterocycles

DOI: 10.3987/com-06-s(w)16

Authors: Larry E. Overman, Brian A. Lanman

Institution: University of California, Irvine

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences

Awards: G4103734621, Practical Chemical Synthesis of Complex Alkaloids, Synthesis of the Phosphatidylinositol 3-Kinase Inhibitor