Year: 1972
Type: article
Abstract: Propranolol was introduced as a 0-adrenergic receptor antagonist, having about ten times the potency of pronethalol against isoprenaline (Black, Crowther, Shanks, Smith, and Dornhorst, I964) while being devoid of intrinsic sympathomimetic activity.A preliminary investigation with systemic racemic propranolol intravenously and by mouth showed that it caused a lowering of ocular tension in patients with glaucoma (Phillips, Howitt, and Rowlands, I967).These observations were confirmed by Cote and Drance (i968) using orally administered propranolol in humans, and by Vale and Phillips (I970) using intravenously administered propranolol in humans and rabbits.Following reports that topical propranolol was also effective in reducing tension (Bucci, J F 82Bilateral open-angle glaucoma None
Source: British Journal of Ophthalmology
Authors: J Vale, A C Gibbs, C I Phillips
Institutions: Princess Alexandra Eye Pavilion, University of Manchester
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2059639666