Work

New Heritable Fragile Site on Chromosome 8 Induced by Distamycin a

Year: 1988

Type: article

Abstract: A possible new heritable fragile site at band 8q24.1, which is known to be a breakpoint in various cancers and contains the c-myc locus, was found in the lymphocytes from a woman with mastopathy. This fragile site was induced by distamycin A treatment, and expressed as gaps and breaks in 18% of the metaphases examined. The lymphocytes from one of her two sons examined also revealed gaps or breaks at the same site of chromosome 8 in 34% of the metaphases. This fragile 8q24.1 band is considered to be a new heritable fragile site induced by distamycin A.

Source: Japanese Journal of Cancer Research

DOI: 10.1111/j.1349-7006.1988.tb01568.x

Authors: Hisako Ochi, Shaw Watanabe, Hiroshi Yamamoto

Institutions: National Cancer Center Research Institute, National Cancer Center Hospital

Language: English

Topic: Genomic variations and chromosomal abnormalities

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2059904995

FWCI: 0.363

Cites: 10

Cited by: 5

Related to: 10