Work

Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure–Activity Relationship

Year: 2008

Type: article

Abstract: A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm0708331

Authors: Ahcène Boumendjel, Julien Boccard, Pierre-Alain Carrupt, Edwige Nicolle, Madeleine Blanc, Annabelle Geze, Luc Choisnard, Denis Wouessidjewe, Eva-Laure Matera, Charles Dumontet

Institutions: University of Geneva, Inserm, Université Joseph Fourier, Université de Lyon, Institut de Chimie Moléculaire de Grenoble, Département de Pharmacochimie Moléculaire, University of Lausanne

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2060896772

FWCI: 5.646

Cites: 18

Cited by: 180

Related to: 10