Prolymphocytic Leukemia ： Report of a Case with Autopsy Findings
Year: 1983
Type: article
Study design: Case Report
Abstract: A case of prolymhocytic leukemia, a rare variant of chronic lymphocytic leukemia, was reported with autopsy findings. The patient was a 65-year-old woman who was chinically characterized by huge splenomegaly, mid lymphadenopathy and red skin eruption due to leukemic cell infiltration. The leukemic cellls in the peripheral blood and in the bone marrow had pale bluish cytoplasm and one large prominent nucleolus. Transmission electron microscopy also revealed a chromatin structure intermediate between that of a mature lymphocyte and that of a lymphoblast. Surfase maker studies suggested T-cell origin. Irradia tion to the spleen and chemotherapy with cyclophosphamide. And vincristine failed to induce remission.
Authors: Masaki Okubo, Y Hiroshige, Kohei Kaku, Toshiaki Kamei, Norio Ishiguro, Noboru Matsumoto, Toshio Kaneko
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W206373354