Work

Complementary surface epitopes, myotropic adhesion and active grip in Trypanosoma cruzi-host cell recognition

Year: 1988

Type: article

Abstract: Plasma membranes with complementary surface epitopes and with essentially the same orientation as tissue infective metacyclic trypomastigotes and epimastigotes of Trypanosoma cruzi adhere to L6 myoblast host cells preferentially to smooth muscle and epithelial cells as a function of time, surface area and concentration in saturation phenomena at 4 and 37 degrees C. The initial adhesion rates are partially calcium ion dependent and, at saturation, they are also dependent on high energy phosphorylated intermediates, exerting an active grip on adherent parasite membranes. These phenomena are consistent with the existence of parasite attachment molecules on the external surface of the plasma membrane and complementary host cell receptor structures with the capacity to bind them.

Source: Molecular and Biochemical Parasitology

DOI: 10.1016/0166-6851(88)90088-6

Authors: Betsy F. von Kreuter, Moyses Sadigursky, Charles A. Santos-Buch

Institution: Cornell University

Language: English

Topic: Trypanosoma species research and implications

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,460