Work

Differential Pulse Voltammetric Determination of Fulvestrant in Pharmaceutical Dosage Forms and Serum Samples

Year: 2011

Type: article

Abstract: The electrooxidation behavior and determination of fulvestrant at a glassy carbon electrode were investigated. The voltammetric study of the model compounds allowed elucidating the possible oxidation mechanism of fulvestrant. The dependence of the peak current and peak potentials on pH, concentration, nature of the buffer, and scan rate was determined. The oxidation of fulvestrant showed a single and irreversible peak at glassy carbon electrode, and the process was found diffusion controlled. Linear responses were obtained for the concentrations between 4 × 10 −6 M and 6 × 10 −5 M in standard samples and between 2 × 10 −5 M and 1 × 10 −4 M in serum samples. The repeatability of the method was found 0.93 RSD%. The repeatability, reproducibility, precision, and accuracy of proposed method were investigated.

Source: International Journal of Electrochemistry

DOI: 10.4061/2011/941583

Authors: Dilek Kul, Burcu Doğan-Topal, Sibel A. Özkan, Bengi Uslu

Institutions: Karadeniz Technical University, Ankara University

Language: English

Topic: Electrochemical Analysis and Applications

Subfield: Electrochemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,000

Funder: Ankara Universitesi