Work

Nuclear pore proteins and the control of genome functions

Year: 2015

Type: preprint

Abstract: Nuclear pore complexes (NPCs) are composed of several copies of ∼30 different proteins called nucleoporins (Nups). NPCs penetrate the nuclear envelope (NE) and regulate the nucleocytoplasmic trafficking of macromolecules. Beyond this vital role, NPC components influence genome functions in a transport-independent manner. Nups play an evolutionarily conserved role in gene expression regulation that, in metazoans, extends into the nuclear interior. Additionally, in proliferative cells, Nups play a crucial role in genome integrity maintenance and mitotic progression. Here we discuss genome-related functions of Nups and their impact on essential DNA metabolism processes such as transcription, chromosome duplication, and segregation.

Source: Genes & Development

DOI: 10.1101/gad.256495.114

Authors: Arkaitz Ibarra, Martin W. Hetzer

Institution: Salk Institute for Biological Studies

Language: English

Topic: Nuclear Structure and Function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: American Cancer Society, National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: The role of the nucleoporin Nup98 in gene regulation, G211874389, Cancer Center Support Grant (CCSG)