Work

Actinoidin A2, a novel glycopeptide : Production, preparative HPLC separation and characterization.

Year: 1987

Type: article

Abstract: An unidentified Nocardia sp. (SK&F-AAJ-193) was isolated and found to produce actinoidin A and a novel analog which we have named actinoidin A2. This new glycopeptide antibiotic differs from actinoidin A by the presence of rhamnose instead of acosamine. This analog was isolated using Dianion HP-20 resin followed by a specific glycopeptide affinity column (Affigel-10-D-Ala-D-Ala). The purification was accomplished using preparative ion-pairing chromatography. Actinoidin A2 is active against Staphylococcus aureus and coagulase-negative Staphylococci although it is less potent than actinoidin A.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.40.165

Authors: J. J. DINGERDISSEN, R. D. SITRIN, P. A. DEPHILLIPS, A. J. GIOVENELLA, S. F. GRAPPEL, R. J. MEHTA, Y. K. OH, C. H. PAN, G. D. ROBERTS, M. C. SHEARER, L. J. NISBET

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Applied Microbiology and Biotechnology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2073056014

FWCI: 0.73

Cites: 15

Cited by: 18

Related to: 10