Work

Suppression of Gl Arrest and Enhancement of G2 Arrest by Inhibitors of Poly(ADP‐ribose) Polymerase: Possible Involvement of Poly(ADP‐ribosyl)ation in Cell Cycle Arrest Following γ‐Irradiation

Year: 1994

Type: article

Abstract: Low-dose gamma-irradiation of mouse embryonic fibroblast C3D2F1 3T3-a cells caused G1 arrest along with G2 arrest and inhibition of replicative DNA synthesis. When the cells were cultured in the presence of inhibitors of poly(ADP-ribose) polymerase [EC 2.4.2.30], such as 3-aminobenzamide, benzamide and luminol, G1 arrest of C3D2F1 3T3-a cells was suppressed and enhancement of G2 arrest was observed. In contrast, 3-aminobenzoic acid, a non-inhibitory analog of 3-aminobenzamide, did not suppress G1 arrest following gamma-irradiation. These results suggest that the poly(ADP-ribosyl)ation reaction is critical for the pathway of G1 arrest and is also involved in the pathway of G2 arrest.

Source: Japanese Journal of Cancer Research

DOI: 10.1111/j.1349-7006.1994.tb02912.x

Authors: Tadashige Nozaki, Mitsuko Masutani, Tetsuya Akagawa, Takashi Sugimura, Hiroyasu Esumi

Institutions: National Cancer Center Research Institute, The University of Tokyo, National Cancer Center Hospital East

Language: English

Topic: PARP inhibition in cancer therapy

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2074444434

FWCI: 0.8

Cites: 17

Cited by: 22

Related to: 10