Work

A Thiourea‐Oxazoline Library with Axial Chirality: Ligand Synthesis and Studies of the Palladium‐Catalyzed Enantioselective Bis(methoxycarbonylation) of Terminal Olefins

Year: 2010

Type: article

Abstract: We report herein the synthesis of novel chiral S,N‐heterobidentate thiourea‐oxazoline ligands and their application to palladium‐catalyzed enantioselective bis(methoxycarbonylation)s of terminal olefins under mild conditions. Copper salts were found to play multiple roles in this reaction. Substituted 2‐phenylsuccinates were obtained in >90% yield and up to 84% ee under optimized conditions.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.201000070