Work

pH Controlled Release of Chromone from Chromone-Fe3O4 Nanoparticles

Year: 2008

Type: article

Abstract: We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja806519m

Authors: Baodui Wang, Chenjie Xu, Jin Xie, Zhengyin Yang, Shouheng Sun

Institutions: Brown University, Lanzhou University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute