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Methods for Equivalence and Noninferiority Testing

Year: 2009

Type: article

Abstract: Classical hypothesis testing focuses on testing whether treatments have differential effects on outcome. However, sometimes clinicians may be more interested in determining whether treatments are equivalent or whether one has noninferior outcomes. We review the hypotheses for these noninferiority and equivalence research questions, consider power and sample size issues, and discuss how to perform such a test for both binary and survival outcomes. The methods are illustrated on 2 recent studies in hematopoietic cell transplantation.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2008.10.004

Authors: Gisela Tunes da Silva, Brent R. Logan, John P. Klein

Institutions: Universidade de São Paulo, Medical College of Wisconsin

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650