Work

Formation of DNA‐Copolymer Fibrils Through an Amyloid‐Like Nucleation Polymerization Mechanism

Year: 2015

Type: article

Abstract: Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes.

Source: Macromolecular Rapid Communications

DOI: 10.1002/marc.201400728

Authors: Dawid Kedracki, Sergey K. Filippov, Nidhi Gour, Helmut Schlaad, Corinne Nardin

Institutions: University of Geneva, Czech Academy of Sciences, Institute of Macromolecular Chemistry, University of Potsdam, Max Planck Institute of Colloids and Interfaces

Language: English

Topic: Supramolecular Self-Assembly in Materials

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2076732207

FWCI: 0.42

Cites: 33

Cited by: 25

Related to: 10