Work

Minimally Invasive Protein Delivery with Rapidly Dissolving Polymer Microneedles

Year: 2008

Type: article

Abstract: A new room-temperature, in situ polymerization process to produce microneedles (see figure), which can encapsulate functional biomolecules and dissolve within minutes, is presented. The dissolution rate and mechanical strength of these polymer microneedles can be tailored by changing monomer composition and microneedle geometry. Drug delivery using micrometer-scale needles that dissolve in the skin could eliminate the pain and dangers of hypodermic needle use.

Source: Advanced Materials

DOI: 10.1002/adma.200701205

Authors: S. P. Sullivan, N. Murthy, M. R. Prausnitz

Institutions: Georgia Institute of Technology, The Wallace H. Coulter Department of Biomedical Engineering

Language: English

Topic: Advancements in Transdermal Drug Delivery

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Allergy and Infectious Diseases, National Institute of Biomedical Imaging and Bioengineering