Work

Sterically Hindered Benzophenones via Rhodium-Catalyzed Oxidative Arylation of Aldehydes

Year: 2008

Type: article

Abstract: Efficient cross-coupling, allowing a straightforward access to congested benzophenones, between aromatic aldehydes and potassium aryltrifluoroborates, is described in the presence of a rhodium/tri-tert-butylphosphane catalyst system and acetone as cosolvent. The use of the stable phosphonium salts of tri-tert-butylphosphane prevented the use of highly oxidizable tri-tert-butylphosphane and allowed a careful control of the stoichiometry with the rhodium.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo801460w

Authors: Olivier Chuzel, Alexander Roesch, Jean-Pierre Genet, Sylvain Darses

Institutions: Centre National de la Recherche Scientifique, Chimie ParisTech - PSL

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Centre National de la Recherche Scientifique

OpenAlex ID: W2077523005

FWCI: 2.666

Cites: 46

Cited by: 51

Related to: 10