Work

Microwave-assisted preparation and antimicrobial activity of O-alkylamino benzofurancarboxylates

Year: 2013

Type: article

Abstract: A series of derivatives of 2 and 3-benzofurancarboxylates were synthesized under microwave-assisted conditions. Their in-vitro antimicrobial properties were assessed. Inhibition by the compounds of the growth of antibiotic-susceptible standards and clinically isolated strains of Gram-positive and Gram-negative bacteria, yeasts, and a human fungal pathogen was moderate to significant. Methyl 5-bromo-7-[2-(N,N-diethylamino)ethoxy]-6-methoxy-2-benzofurancarboxylate hydrochloride was identified as the most active compound (MIC 3–12 × 10−3 μmol/cm3 against Gram-positive bacteria; MIC 9.4 × 10−2 μmol/cm3 against Candida and Aspergillus brasiliensis). The molecular and crystal structures of 2-(N,N-diethylamino)ethyl 6-acetyl-5-hydroxy-2-methyl-3-benzofurancarboxylate were established by single-crystal X-ray diffraction. .

Source: Monatshefte für Chemie - Chemical Monthly

DOI: 10.1007/s00706-013-1067-7

Authors: Kinga Ostrowska, Elżbieta Hejchman, Irena Wolska, Hanna Kruszewska, Dorota Maciejewska

Institutions: Medical University of Warsaw, Adam Mickiewicz University in Poznań, Narodowy Instytut Leków

Language: English

Topic: Synthesis and Biological Evaluation

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,890