Year: 2014
Type: article
Abstract: Objective: Vanillin is known to have antimutagenic, anti-invasive, and metastatic suppression potential.Antinociceptive property in acetic acid and antioxidant and hepatoprotective properties in carbon tetrachloridetreated rats have also been demonstrated.Objective of this study is to evaluate the anti-inflammatory and antinociceptive activity of vanillin.Materials and Methods: The drugs and fine chemicals were purchased from Sigma Aldrich, Ranbaxy, India and MS Pharmaceuticals, India.Experimental Rats were assigned to groups of six animals each and anti-inflammatory activity was evaluated using carrageenan induced rat paw aedema and anti-nocicetion was done using tail flick method.Carrageenan-induced paw edema was used to evaluate pre and post anti-inflammatory activity and tail flick method was used in the evaluation of antinociceptive activity.Two-way analysis of variance (ANOVA) followed by Student's t-test was used for statistical analysis in both the studies.Results: There was significant decrease in the paw volume at 50 and 100 mg/kg doses of vanillin when compared with control group.Meanwhile, an increase in percentage maximum possible effect (MPE) was seen by same doses of vanillin.Conclusion: It has been concluded from the findings that vanillin possesses the antiinflammatory and antinociceptive effect by virtue of its antihistaminic and central analgesic activity, respectively.
Language: English
Subfield: Biotechnology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2079738121