Work

Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene

Year: 2011

Type: article

Abstract: We report here a facile preparation of highly water-soluble derivatives C(70)[p-C(6)H(4)(CH(2))(n)COOH](8) (n = 2, 3) starting from readily available chlorinated [70]fullerene precursors C(70)Cl(8) and C(70)Cl(10). The synthesized fullerene derivatives showed pronounced antiviral activity in vitro, particularly against human immunodeficiency virus (HIV) and influenza A virus (subtypes H1N1 and H3N2).

Source: Chemical Communications

DOI: 10.1039/c1cc12209f

Authors: Alexey B. Kornev, Alexander S. Peregudov, Vyacheslav M. Martynenko, Jan Balzarini, Bart Hoorelbeke, Pavel A. Troshin

Institutions: Institute of Problems of Chemical Physics, Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds, Rega Institute for Medical Research

Language: English

Topic: Fullerene Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Russian Foundation for Basic Research, Federal Agency for Science and Innovation