The Novel Gluconeogenesis Inhibitors FR225659 and Related Compounds that Originate from Helicomyces sp. No. 19353 I. Taxonomy, Fermentation, Isolation and Physico-chemical Properties
Year: 2003
Type: article
Abstract: FR225659 and four related compounds are novel gluconeogenesis inhibitors that consist of a novel acyl-group and three abnormal amino acids. They were isolated from the culture broth of Helicomyces sp. No. 19353 and can be purified by absorptive resin and reverse-phase column chromatography. They are potent inhibitors of gluconeogenesis in primary cultured rat hepatocytes and thus may be useful as anti-diabetic agents.
Source: The Journal of Antibiotics
Authors: YOSHIHIRO OHTSU, HIROMI SASAMURA, YASUHISA TSURUMI, SEIJI YOSHIMURA, SHIGEHIRO TAKASE, MICHIZANE HASHIMOTO, TOSHIHIRO SHIBATA, MOTOHIRO HINO, TAKASHI FUJII
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2084769428