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Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs

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Year: 2014
Type: article
Source: Nature Structural & Molecular Biology
DOI: 10.1038/nsmb.2874
Authors: Philip P Chamberlain, Antonia Lopez-Girona, Karen Miller, Gilles Carmel, Barbra Pagarigan, Barbara Chie-Leon, Emily Rychak, Laura G Corral, Yan J Ren, Maria Wang, Mariko Riley, Silvia L Delker, Takumi Ito, Hideki Ando, Tomoyuki Mori, Yoshinori Hirano, Hiroshi Handa, Toshio Hakoshima, Thomas O Daniel, Brian E Cathers
Institutions: Tokyo Medical University, Nara Institute of Science and Technology
Language: English

Topic: Protein Degradation and Inhibitors
Subfield: Molecular Biology
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: closed

Funder: Japan Society for the Promotion of Science
Awards: Structural study of the novel transcription mechanism essential for root development of higher plants, Elucidation of the molecular mechanism of the anti-cancer activity of IMiDs, Basic study of a bionanodevice for medical application and expansion for its use.
OpenAlex ID: W2084778320
FWCI: 10.52
Cites: 43
Cited by: 535
Related to: 10
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