Work

Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery

Year: 2010

Type: article

Abstract: Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations of polyethylene glycol (PEG 6000), glycerol and Tween 80 as erosion enhancers by compression and molding technique. Formulations were subjected to in vitro drug release by the USP dissolution method, while promising formulations were subjected to in vitro drug release by the agar gel method and also to stability studies. It was observed that glyceryl monostearate formed hydrophobic matrix and delayed the drug delivery. Antibiotic release profile was controlled by using different combinations of erosion enhancers. The formulation prepared by the compression method showed more delayed release compared to formulations prepared by the molding method.

Source: Acta Pharmaceutica

DOI: 10.2478/v10007-010-0005-z

Authors: Vijay Mathur, Rajesh Mudnaik, Laxmikant Barde, Arghya Roy, Umesh Shivhare, Kishore Bhusari

Institution: Shri Vidyarthi Sudhar Sangh’s Nagpur College of Pharmacy

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $970