Work

Anti-HIV-1 Protease Activity of Lanostane Triterpenes from the Vietnamese Mushroom Ganoderma colossum

Year: 2008

Type: article

Abstract: Four new lanostane triterpenes, colossolactone V (1), colossolactone VI (2), colossolactone VII (3), and colossolactone VIII (4), were isolated from the fruiting bodies of the Vietnamese mushroom Ganoderma colossum, together with the known compound colossolactone E (5). The structures of 1- 4 were assigned on the basis of spectroscopic evidence, and their absolute configurations were determined by CD spectroscopy and the Mosher ester method. Compounds 1- 5, as well as two previously isolated compounds [schisanlactone A (6) and colossolactone G (7)] from the same mushroom, were evaluated for inhibition of HIV-1 protease, with IC 50 values for the most potent compounds ranging from 5 to 13 microg/mL.

Source: Journal of Natural Products

DOI: 10.1021/np8001139

Authors: Riham Salah El Dine, Ali M. El Halawany, Chao-Mei Ma, Masao Hattori

Institutions: University of Toyama, Institute of Natural Medicine, University of Toyama

Language: English

Topic: Fungal Biology and Applications

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2086233644

FWCI: 2.276

Cites: 14

Cited by: 114

Related to: 10