Year: 1952
Type: article
Abstract: The methods available for testing the analgesic activity of a compound in animals can be divided into three groups, depending on the device used for producing pain.D' Amour and Smith (1941), Thorp (1946), Davies, Raventos, and Walpole (1946), and Woolfe and Macdonald (1944) used heat as the physical agent for producing pain.Eddy (1928, 1932), and Green, Young, and Godfrey (1950) used mechanical pressure; Macht and Macht (1938) and Dodds, Lawson, Simpson, and Williams (1945) used electric shocks for the same purpose.The methods of Thorp (1946) and of Davies, Raventos, and Walpole (1946) have both been carefully studied in this laboratory without much success, but a method devised by Reinhard and E. J. de Beer has given more satisfactory results.This method has not been published by the authors, but has been described with their permission by Burn (1950), who suggested that the estimation of the degree of analgesia in each mouse should be abandoned, and that the percentage of mice in which there was some analgesia should be recorded instead.This has now been done and a linear relation between
Author: R. SINGH GREWAL
Institution: University of Oxford
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2086794047