Secondary Glioblastoma Remarkably Reduced by Steroid Administration After Anaplastic Transformation from Gliomatosis Cerebri —Case Report—
Year: 1998
Type: article
Study design: Case Report
Abstract: A 45-year-old female presented with gliomatosis cerebri manifesting as hemiballismus-like involuntary movement in the arm, motor weakness in the leg, and hypesthesia in her left side. Computed tomography showed only diffuse swelling of the right cerebral hemisphere, but T2-weighted magnetic resonance imaging revealed a diffuse lesion spreading from the right thalamus to the temporal, parietal, and occipital lobes on the same side. No abnormal enhancement was recognized. Cerebral angiography showed no specific finding. A right occipital lobectomy was performed to confirm the diagnosis of gliomatosis cerebri. Anaplastic transformation was recognized 5 months later. The disease did not resolve with radiation or interferon administration, but steroid therapy achieved remarkably effective tumor regression. The patient died due to pneumonia. Autopsy showed the features of diffuse glioblastoma. Steroid therapy may be an effective treatment for gliomatosis cerebri before the terminal stage.
Source: Neurologia medico-chirurgica
DOI: 10.2176/nmc.38.865
Authors: Yuichi HIROSE, Takuro HAYASHI, Masachika SAGOH, Hideki MURAKAMI
Institution: Ashikaga Red Cross Hospital
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2086983733