Work

NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One‐Pot Synthesis of Novel Spiro and Condensed Indole Derivatives

Year: 2012

Type: article

Abstract: An efficient catalytic protocol for the synthesis of novel spiro[indoline‐3,4′‐pyrano[2,3‐c]thiazole]carbonitriles and condensed thiazolo[5′′,4′′:5′,6′]pyrano[4′,3′:3,4]furo[2,3‐b]indole derivatives is developed in a one‐pot three‐component approach involving substituted 1H‐indole‐2,3‐diones, activated methylene reagent, and 2‐thioxo‐4‐thiazolidinone under conventional heating and microwave irradiation. This paper describes the use of NiO nanoparticles as catalyst for the synthesis of novel spiro and condensed indole derivatives by Knoevenagel condensation followed by Michael addition. The advantageous features of this methodology are operational simplicity, high yield processing, and easy handling. The particle size of NiO nanoparticle was determined by XRD. After reaction course, NiO nanoparticles can be recycled and reused without any apparent loss of activity.

Source: Journal of Chemistry

DOI: 10.1155/2013/606259

Authors: Harshita Sachdeva, Diksha Dwivedi, R. R. Bhattacharjee, Sarita Khaturia, Rekha Saroj

Institution: Mody University of Science and Technology

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $2,160

Funder: University of the Punjab