Work

Magnesium Stearate as Anti-Tacking Agent in Acrylic Polymer Films Intended for Gas-Entrapped Floating Delivery System

Year: 2012

Type: article

Abstract: In development of effervescent-based floating tablets, acrylic polymer is used to prepare a gas-entrapped membrane of the system. The tackiness of this acrylic polymer film causes tablet agglomeration, leading to failure in floatation. Thus, the aim of this study was to investigate the effect of magnesium stearate (MS) used as anti-tacking agent on mechanical and wetting properties of the acrylic polymer (Eudragit® RL 30D) films. Incorporating MS resulted in the films with a slightly lowered puncture strength, a highly lowered elongation and an increased contact angle. These results indicated that flexibility and wettability of these films were reduced by addition of MS. Furthermore, the film tackiness measurement by peel test showed that 5% (w/w) of MS could significantly decrease the tackiness of the films. It was demonstrated that MS was a promising candidate to be used as an anti-tacking agent for effervescent-based floating tablets.

Source: Advanced materials research

DOI: 10.4028/www.scientific.net/amr.506.497

Authors: Worawut Kriangkrai, Satit Puttipipatkhachorn, Pornsak Sriamornsak, T. Pongjanyakul, Srisagul Sungthongjeen

Institutions: Naresuan University, Mahidol University, Silpakorn University, Khon Kaen University

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: hybrid

OpenAlex ID: W2089508271

FWCI: 0.219

Cites: 7

Cited by: 2

Related to: 10