Work

Plasmid-determined resistance to fosfomycin in Serratia marcescens

Year: 1980

Type: article

Abstract: Multiple-antibiotic-resistant strains of Serratia marcescens isolated from hospitalized patients were examined for their ability to transfer antibiotic resistance to Escherichia coli by conjugation. Two different patterns of linked transferable resistance were found among the transconjugants. The first comprised resistance to carbenicillin, streptomycin, and fosfomycin; the second, and more common, pattern included resistance to carbenicillin, streptomycin, kanamycin, gentamicin, tetracycline, chloramphenicol, sulfonamide, and fosfomycin. The two types of transconjugant strains carried a single plasmid of either 57 or 97 megadaltons in size. Both of these plasmids are present in parental S. marcescens strains resistant to fosfomycin. The 57-megadalton plasmid was transformed into E. coli.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.18.2.215

Authors: C Mendoza, J M Garcia, J Llaneza, F J Mendez, C Hardisson, J M Ortiz

Institutions: Universidad de Oviedo, Universidad De Santander

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Microbiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2090120751

FWCI: 1.141

Cites: 22

Cited by: 77

Related to: 10