Year: 2012
Type: article
Abstract: A decrease in high density lipoprotein-cholesterol (HDL-C) is a strong risk factor for atherosclerotic disorders in Japan, probably more important than an increase in low density lipoprotein-cholesterol (LDL-C). While there are rational grounds for the argument that elevation of HDL-C leads to decreased risk, there has as yet been no direct evidence of such an effect. If elevation of HDL-C decreases the risk, this effect is expected throughout the normal range of HDL-C or perhaps even higher than that. Simulation based on epidemiological data indicated that it may eventually reduce the incidence of ischemic heart disease by 60-70% in Japan. In the risk management guideline, "low" HDL-C is presently defined as 40 mg/dL or below. While there is no evidence that strongly urges a change in this definition, the results of epidemiological studies support "The higher the HDL-C level, the lower the risk,"even in the "normal range". Elevation of the HDL-C level may reduce the risk, probably at least up to 70 mg/dL; however, there are no supportive data for this effect still being obtained over 80 mg/dL. Patients with homozygous CETP deficiency should be followed-up while controlling other risk factors, so as not to dismiss the possibility of a risk increase with an extremely elevated HDL-C level.
DOI: 10.5551/jat.11452
Institutions: Chubu University, The University of Osaka, Jichi Medical University, University of Tsukuba, Nippon Medical School, Toho University, Toho University Medical Center Sakura Hospital, University of the Ryukyus, Chiba University, Kanazawa University, Kyoto University, National Cerebral and Cardiovascular Center Research Institute, Ohu University, Ohu University Hospital, Nagoya University, University of Tokyo Hospital
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Investigation of the regression of advanced atherosclerosis through the regulation of cellular senescence-custom-made therapy to Japanese elderly-, Elucidation of the roles of Neuromedin U on development of atherosclerosis and its therapeutic application, Geriatric and gerontological approach for asian elderly to prevent their atherosclerotic disease and get successful aging., Nutritional regulation of sterol metabolism in development of lifestyle-related diseases, Establishing clinical evidence for prevention of lifestyle-related disease and lifestyle intervention
OpenAlex ID: W2090172013