Work

Atrophy of myoepithelial cells in parotid glands of diabetic mice; detection using skeletal muscle actin, a novel marker

Year: 2013

Type: article

Abstract: In mouse parotid glands, we found expression of skeletal muscle actin (actin-α1) protein and mRNA. We isolated myoepithelial cells from the mouse parotid glands and investigated their actin-α1 expression because smooth muscle actin (actin-α2) has been used as a marker for myoepithelial cells. We used actin-α1 expression to identify pathological changes in diabetic non-obese diabetic (NOD; NOD/ShiJcl) mice-a mouse model for Sjögren's syndrome-and found myoepithelial cells to be decreased or atrophied in the diabetic state.

Source: FEBS Open Bio

DOI: 10.1016/j.fob.2013.01.009

Authors: Tomoko Nashida, Sumio Yoshie, Maiko Haga-Tsujimura, Akane Imai, Hiromi Shimomura

Institution: Nippon Dental University

Language: English

Topic: Salivary Gland Disorders and Functions

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,210