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Pregnancy Outcome in Nephrotic Syndrome with Mixed Connective Tissue Disease

Year: 2001

Type: article

Abstract: We describe two pregnancies of a young woman with mixed connective tissue disease. In June 1983, she was diagnosed as having Raynaud's phenomenon, arthralgia, and proteinuria. She then developed nephrotic syndrome. Methylprednisolone was initially prescribed at a large dose of 1 g/day which was slowly tapered to 5 mg/day. The proteinuria disappeared. During both pregnancies (the first beginning in December 1988 and the second in May 1992), the patient was placed on a prednisolone maintenance dose (5 mg/day). Both neonates were born healthy at term with no complications. Continuing prednisolone may be useful in pregnant women, and aggressive treatment to prevent mixed connective tissue disease exacerbation may be appropriate during pregnancy.

Source: The Nephron journals/Nephron journals

DOI: 10.1159/000046100

Authors: Yoshio Horita, Sei Tsunoda, Takashi Inenaga, Yuhei Kawano, Hatsue Ishibashi-Ueda, Yoshihide Chiba, Shuichi Takishita

Institutions: National Cerebral and Cardiovascular Center, Nagasaki University, University of the Ryukyus

Language: English

Topic: Pregnancy and Medication Impact

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2093180508

FWCI: 0.892

Cites: 18

Cited by: 8

Related to: 10