Work

Endoplasmic Reticulum Stress and Cancer

Year: 2014

Type: review

Abstract: The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress and cancer, and particularly the involvement of the UPR. The UPR seems to adjust the paradoxical microenvironment of cancer and, as such, is one of resistance mechanisms against cancer therapy. This review describes the activity of different UPRs involved in tumorigenesis and resistance to cancer therapy.

Source: Journal of Cancer Prevention

DOI: 10.15430/jcp.2014.19.2.75

Authors: Raj Kumar Yadav, Soo-Wan Chae, Hyung-Ryong Kim, Han Jung Chae

Institutions: Jeonbuk National University, Wonkwang University

Language: English

Topic: Endoplasmic Reticulum Stress and Disease

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Research Foundation