Work

Comparative Nephrotoxicity of Cisplatin and Nedaplatin:Mechanisms and Histopathological Characteristics

Year: 2011

Type: article

Abstract: The antineoplastic platinum complexes cisplatin and its analogues are widely used in the chemotherapy of a variety of human malignancies, and are especially active against several types of cancers. Nedaplatin is a second-generation platinum complex with reduced nephrotoxicity. However, their use commonly causes nephrotoxicity due to a lack of tumor tissue selectivity. Several recent studies have provided significant insights into the molecular and histopathological events associated with nedaplatin nephrotoxicity. In this review, we summarize findings concerning the renal histopathology and molecular pathogenesis induced by antineoplastic platinum complexes, with a particular focus on the comparative nephrotoxicity of cisplatin and nedaplatin in rats.

Source: Journal of Toxicologic Pathology

DOI: 10.1293/tox.24.87

Authors: Takeki Uehara, Jyoji Yamate, Mikinori Torii, Toshiyuki Maruyama

Institutions: Shionogi (Japan), Osaka Prefecture University

Language: English

Topic: Chemotherapy-induced organ toxicity mitigation

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2094903382

FWCI: 3.439

Cites: 73

Cited by: 52

Related to: 10